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KMID : 0861120020060020086
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Korean Journal of Oriental Preventive Medicine
2002 Volume.6 No. 2 p.86 ~ p.94
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Effects of Ligusticum Chuanxiang on blood circulation and oxidative stress
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Park Yeong-Chul
Lee Sun-Dong
Heo Yong
Kim Hyun-Soo
Lee In-Seon
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Abstract
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Ligusticum Chuanxiong and its components were reviewed in terms of pharmacodynamic mechanisms. Three components of about 40 chemical components in Chuanxiong tetramethylpyrazine, ferulinolol and Butylidenephthalide have mainly been studied for its pharmacodynamic mechanisms which are focused on the increase in blood flow and anti-oxidative stress. The mechanisms for the effects of Chuanxiong on the increase in blood flow can be summarized as four ways, 1) anti-coagulation 2) blocker of adrenergic receptor 3) cellular control of Ca++ level 4) collagen synthesis. Chuanxiong also showed the effectiveness on free radical-induced injury. It seems that its effectiveness is also related to the mechanisms for the increase in blood flow.
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KEYWORD
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